Bond CT ; Francis RC ; Fernald RD ; Adelman JP ;

Mol Endocrinol vol. 5 (7)   pp. 931-7, Jui 1991

Vollum Institute, Oregon Health Sciences University, Portland 97201.

Reproductive maturity among male African cichlids Haplochromis burtoni is cued by a series of environmental and social interactions and is mediated physiologically by GnRH. A cDNA clone encoding the precursor for GnRH was isolated from this teleost. The molecular architecture of the predicted prohormone is analogous to that of the previously characterized mammalian forms; however, the predicted sequence of the associated peptide is strikingly different. Attempts to isolate a putative second precursor using low stringency hybridization were not successful despite evidence that a second related decapeptide exists in at least some teleost species.

Amino acid sequence ;  Animal ;  Base Sequence ;  Blotting,Northern ;  Comparative Study ;  DNA: genetics: isolation & purification ;  Gonadorelin: chemistry: genetics ;  Male ;  Molecular Sequence Data ;  Perch: genetics ;  Protein Precursors: chemistry: genetics ;  Sequence Homology,Nucleic Acid ;  Species Specificity ;  Support,U.S.Gov't,P.H.S. ;  40530 ;