The effect of increasing levels of dietary fish oil rich in eicosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse
Br J Nutr
The influence of increasing intakes of fish oil on spleen leucocyte phospholipid fatty acid composition and cell-mediated immunity was studied in the mouse using a popliteal lymph node assay technique. The immune response was suppressed by 160 g fish oil/kg diet, but not by lower doses. The proportion of 20:5n-3 in spleen leucocyte phospholipid increased from 0.14 in the controls to 3.8, 7.2, 8.5 and 9.4% in the animals fed on 25, 50, 100 and 160 g fish oil/kg diet; the proportion of 22:6n-3 increased from 5.1 in the controls to 12.1, 12.2, 12.8 and 12.9% respectively. It is concluded that moderate intakes of fish oil are not immunosuppressive.
5,8,11,14,17-Eicosapentaenoic Acid: administration & dosage ; Animal ; Comparative Study ; Docosahexaenoic Acids: administration & dosage ; Fish Oils: administration & dosage: chemistry: immunology ; Immunity,Cellular: drug effects ; Lymphocytes: chemistry: drug effects ; Male ; Mice ; Mice,Inbred CBA ; Phospholipids: analysis ; 36960 ;