Katharios P ; Iliopoulou-Georgudaki J ; Antimisiaris S ; Verri T ; Toma P ; Acierno R ; Maffia M ;

Journal of Applied Ichthyology vol. 20 (5)   pp. 422-426, 1 Oct 2004

Summary The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg-1). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non-compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml-1 kg-1 1 h post-treatment. The area under the curve (AUC) cephalexin was 17.394 mg.h kg-1 and the elimination half-life of 1.83 h

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