Fish & Shellfish Immunology

Comparative transcriptomic analysis reveals the gene expression profiles in the liver and spleen of Japanese pufferfish (Takifugu rubripes) in response to Vibrio harveyi infection

Publication date: July 2019

Source: Fish & Shellfish Immunology, Volume 90

Author(s): Hongyu Peng, Boxue Yang, Boyan Li, Zhonglu Cai, Qianjin Cui, Mingkang Chen, Xia Liu, Xu Yang, Chen Jiang


Japanese pufferfish (Takifugu rubripes) is one of the main marine aquatic fish species cultured in Asia due to its high nutritional value. In recent years, disease caused by Vibrio harveyi infections have led to serious mortality in Japanese pufferfish industry. To understand the complex molecular mechanisms between V. harveyi and Japanese pufferfish, we performed a transcriptome analysis of liver and spleen samples from Japanese pufferfish at 1 and 2 day post-infection. Between-group comparisons revealed 922 genes that were significantly differentially expressed. The altered genes emphasized the function in several immune related pathways including MAPK signaling pathway, JAK-STAT signaling pathway, toll-like receptor signaling pathway, cytokine-cytokine receptor interaction and lysosomal pathway. The data generated in this study provided insight into the responses of Japanese pufferfish against V. harveyi at the transcriptome level, promoting our comprehensive understanding of immune responses for aquatic animal against V. harveyi.

Glossaire technique

Substance sécrétée par les lymphocytes (globules blancs) et les...
Le genre Takifugu est un genre comprenant des poissons appelés fugu,...
Manifestation pathologique due à l'action des microbes.
Se réfère à la mer, depuis la haute mer jusqu'au niveau de la marée haute...